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Molecular genetics of inflammatory bowel disease /

Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowle...

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Bibliographic Details
Corporate Author: SpringerLink (Online service)
Format: Online Book
Published: New York : Springer, 2013.
Online Access:Online version
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Table of Contents:
  • Part I:
  • The Foundation of IBD Genetics, Human and Animal Studies.
  • A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges /
  • Xinjun Cindy Zhu and Richard P. MacDermott
  • Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies /
  • Jonas Halfvarson
  • Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease /
  • Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan
  • Part II:
  • The Genetic and Molecular Makeup of Inflammatory Bowel Disease.
  • Complex Disease Genes and Their Discovery /
  • Jeffrey C. Barrett and Mark J. Daly
  • The Genetics of Crohn's Disease /
  • Andre Franke and Miles Parkes
  • Genetics of Ulcerative Colitis /
  • Mauro D'Amato, Catherine Labbé and John D. Rioux
  • Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases /
  • Charlie W. Lees and Alexandra Zhernakova
  • Molecular Profiling of IBD Subtypes/Response to Therapy /
  • Isabelle Cleynen and Séverine Vermeire
  • Epigenetics of Inflammatory Bowel Disease /
  • Robert Häsler, Stefan Schreiber and Stephan Beck
  • Part III:
  • Pathogenetic Pathways in Inflammatory Bowel Disease.
  • Nod1 and Nod2 and the Immune Response to Bacteria /
  • Maria Kaparakis-Liaskos, Dana J. Philpott
  • The IL23-Th17 Axis in Intestinal Inflammation /
  • Kevin J. Maloy
  • Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics /
  • Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno
  • The Epithelial Barrier /
  • Stefan Koch, Asma Nusrat and Charles A. Parkos
  • Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" /
  • Nouara Lhocine and Philippe J. Sansonetti
  • Cytokines in Inflammatory Bowel Disease /
  • Matthias A. Engel and Markus F. Neurath
  • Part IV:
  • Concluding Remarks and Future Perspectives.
  • Towards Personalized Therapy in Inflammatory Bowel Disease /
  • Dermot P. B. McGovern